Evaluation in a Dog Model of Three Antimicrobial Glassy Coatings: Prevention of Bone Loss around Implants and Microbial Assessments
Identifieur interne : 001172 ( Main/Exploration ); précédent : 001171; suivant : 001173Evaluation in a Dog Model of Three Antimicrobial Glassy Coatings: Prevention of Bone Loss around Implants and Microbial Assessments
Auteurs : Roberto L Pez-Píriz [Espagne] ; Eva Solá-Linares [Espagne] ; Mercedes Rodriguez-Portugal [Espagne] ; Beatriz Malpica [Espagne] ; Idoia Díaz-Güemes [Espagne] ; Silvia Enciso [Espagne] ; Leticia Esteban-Tejeda [Irlande (pays)] ; Belén Cabal [Espagne] ; Juan José Granizo [Espagne] ; José Serafín Moya [Espagne] ; Ram N Torrecillas [Espagne]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
The aim of the present study is to evaluate, in a ligature-induced peri-implantitis model, the efficacy of three antimicrobial glassy coatings in the prevention of biofilm formation, intrasulcular bacterial growth and the resulting peri-implant bone loss.
Mandibular premolars were bilaterally extracted from five beagle dogs. Four dental implants were inserted on each hemiarch. Eight weeks after, one control zirconia abutment and three with different bactericidal coatings (G1n-Ag, ZnO35, G3) were connected. After a plaque control period, bacterial accumulation was allowed and biofilm formation on abutments was observed by Scanning Electron Microscopy (SEM). Peri-implantitis was induced by cotton ligatures. Microbial samples and peri-implant crestal bone levels of all implant sites were obtained before, during and after the breakdown period.
During experimental induce peri-implantitis: colony forming units counts from intrasulcular microbial samples at implants with G1n-Ag coated abutment remained close to the basal inoculum; G3 and ZnO35 coatings showed similar low counts; and anaerobic bacterias counts at control abutments exhibited a logarithmic increase by more than 2. Bone loss during passive breakdown period was no statistically significant. Additional bone loss occurred during ligature-induce breakdown: 0.71 (SD 0.48) at G3 coating, 0.57 (SD 0.36) at ZnO35 coating, 0.74 (SD 0.47) at G1n-Ag coating, and 1.29 (SD 0.45) at control abutments; and statistically significant differences (p<0.001) were found. The lowest bone loss at the end of the experiment was exhibited by implants dressing G3 coated abutments (mean 2.1; SD 0.42).
Antimicrobial glassy coatings could be a useful tool to ward off, diminish or delay peri-implantitis progression.
Url:
DOI: 10.1371/journal.pone.0140374
PubMed: 26489088
PubMed Central: 4619200
Affiliations:
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<front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Objectives</title>
<p>The aim of the present study is to evaluate, in a ligature-induced peri-implantitis model, the efficacy of three antimicrobial glassy coatings in the prevention of biofilm formation, intrasulcular bacterial growth and the resulting peri-implant bone loss.</p>
</sec>
<sec id="sec002"><title>Methods</title>
<p>Mandibular premolars were bilaterally extracted from five beagle dogs. Four dental implants were inserted on each hemiarch. Eight weeks after, one control zirconia abutment and three with different bactericidal coatings (G1n-Ag, ZnO35, G3) were connected. After a plaque control period, bacterial accumulation was allowed and biofilm formation on abutments was observed by Scanning Electron Microscopy (SEM). Peri-implantitis was induced by cotton ligatures. Microbial samples and peri-implant crestal bone levels of all implant sites were obtained before, during and after the breakdown period.</p>
</sec>
<sec id="sec003"><title>Results</title>
<p>During experimental induce peri-implantitis: colony forming units counts from intrasulcular microbial samples at implants with G1n-Ag coated abutment remained close to the basal inoculum; G3 and ZnO35 coatings showed similar low counts; and anaerobic bacterias counts at control abutments exhibited a logarithmic increase by more than 2. Bone loss during passive breakdown period was no statistically significant. Additional bone loss occurred during ligature-induce breakdown: 0.71 (SD 0.48) at G3 coating, 0.57 (SD 0.36) at ZnO35 coating, 0.74 (SD 0.47) at G1n-Ag coating, and 1.29 (SD 0.45) at control abutments; and statistically significant differences (p<0.001) were found. The lowest bone loss at the end of the experiment was exhibited by implants dressing G3 coated abutments (mean 2.1; SD 0.42).</p>
</sec>
<sec id="sec004"><title>Significance</title>
<p>Antimicrobial glassy coatings could be a useful tool to ward off, diminish or delay peri-implantitis progression.</p>
</sec>
</div>
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</TEI>
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<li>Irlande (pays)</li>
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<tree><country name="Espagne"><noRegion><name sortKey="L Pez Piriz, Roberto" sort="L Pez Piriz, Roberto" uniqKey="L Pez Piriz R" first="Roberto" last="L Pez-Píriz">Roberto L Pez-Píriz</name>
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<name sortKey="Malpica, Beatriz" sort="Malpica, Beatriz" uniqKey="Malpica B" first="Beatriz" last="Malpica">Beatriz Malpica</name>
<name sortKey="Moya, Jose Serafin" sort="Moya, Jose Serafin" uniqKey="Moya J" first="José Serafín" last="Moya">José Serafín Moya</name>
<name sortKey="Rodriguez Portugal, Mercedes" sort="Rodriguez Portugal, Mercedes" uniqKey="Rodriguez Portugal M" first="Mercedes" last="Rodriguez-Portugal">Mercedes Rodriguez-Portugal</name>
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<name sortKey="Torrecillas, Ram N" sort="Torrecillas, Ram N" uniqKey="Torrecillas R" first="Ram N" last="Torrecillas">Ram N Torrecillas</name>
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